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Updated: Jun 24, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
[Complementary treatments of chronic viral hepatitis C]
Thierry Thevenot1, Vincent Di Martino, Françoise Lunel-Fabiani
1Service d'Hépatologie et de Soins Intensifs Digestifs, Service d'Hépatologie, Hôpital Universitaire Jean Minjoz, Besançon. tthevenot@chu-besancon.fr
Abstract:
Pegylated interferon and ribavirin combination therapy represent the standard-of-care treatment for chronic hepatitis C, that allows to cure more than half of the patients. However, the success of this bitherapy is in balance with numerous side effects, especially hematologic and psychiatric. This review is focused on complementary treatments (erythropoietin, G-CSF, vitamin E, glutathion, ursodeoxycholic acid and antidepressants) likely to bring a benefit in maintaining adequate interferon and ribavirin dosages and in improving quality of life. This analysis has been performed by using the Medline(R) data base and with data from laboratories which commercialized these molecules. Erythropoietin, G-CSF and antidepressants are the best tools to optimize the bitherapy in its dose and its duration while privileging the quality of life of HCV-infected patients.
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