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Renal injury in complete ureteric obstruction. A functional and morphological study
J P Kelleher1, A J Wakefield, I Gordon
1Institute of Child Health, London, UK.
Urological Research
|January 1, 1991
Summary
This study reveals how acute and chronic ureteric obstruction causes reno-vascular injury in porcine kidneys. Early obstruction leads to vasodilatation and segmental defects, while chronic obstruction causes vasoconstriction and reduced perfusion.
Area of Science:
- Nephrology
- Vascular Biology
- Urology
Background:
- Obstructive uropathy can lead to significant kidney damage.
- Understanding the reno-vascular changes is crucial for managing kidney injury.
Purpose of the Study:
- To investigate the reno-vascular injury in porcine kidneys during acute and chronic ureteric obstruction.
- To correlate functional changes with microvascular alterations.
Main Methods:
- Utilized multipapillary porcine kidney model.
- Measured upper tract pressure, [99mTc]-dimercaptosuccinic acid (DMSA) uptake for function.
- Assessed renal perfusion via resin casting and scanning electron microscopy (SEM).
Main Results:
- Acute obstruction (30 min): Segmental defects, afferent arteriolar vasodilatation, reduced cortical perfusion.
- Chronic obstruction (20 days): Reduced outer cortical perfusion, afferent arteriolar vasoconstriction.
Conclusions:
- Obstructive uropathy induces distinct reno-vascular injury patterns.
- Segmental injury and perfusion changes are key features in multipapillary kidneys.
- Findings contribute to understanding obstructive nephropathy pathogenesis.