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The evolution of azelaic acid.

Alan B Fleischer1

  • 1Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Cutis
|March 29, 2006
PubMed
Summary

Azelaic acid, a dicarboxylic acid, has evolved from treating hyperpigmentation to effectively managing acne vulgaris and inflammatory rosacea. This review covers 25 years of research on its therapeutic applications in dermatology.

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Area of Science:

  • Dermatology and Cutaneous Science
  • Organic Chemistry
  • Pharmacology

Background:

  • Azelaic acid (AzA) is a naturally occurring dicarboxylic acid with a history in treating skin conditions.
  • Its therapeutic journey spans over 25 years, evolving significantly in dermatological applications.

Purpose of the Study:

  • To review and summarize research on Azelaic acid over the past 25 years.
  • To track the progression of AzA from a hyperpigmentation treatment to a therapy for acne and rosacea.

Main Methods:

  • Comprehensive literature review of studies on Azelaic acid.
  • Analysis of research data from the last 25 years.
  • Synthesis of findings on AzA's efficacy in various dermatological conditions.

Main Results:

  • Azelaic acid has demonstrated efficacy in treating acne vulgaris.
  • AzA is also a recognized therapy for inflammatory (papulopustular) rosacea.
  • The compound's application has expanded beyond hyperpigmentation management.

Conclusions:

  • Azelaic acid is a versatile therapeutic agent in dermatology.
  • Its role has expanded significantly, offering treatment options for acne and rosacea.
  • Continued research supports AzA's place in managing common skin disorders.

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