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Photodynamic therapy and detection of high-grade gliomas
Steen Madsen1, Henry Hirschberg
1Department of Health Physics, Las Vegas Cancer Research Center, University of Nevada, Las Vegas, NV 89154-3037, USA. steenm@ccmail.nevada.edu
Abstract:
The first reported use of photodynamic therapy (PDT) for the treatment of high-grade gliomas occurred in 1981. In the intervening years there have been relatively few clinical trials to investigate the efficacy of this therapeutic modality for the treatment of gliomas. This is due, in part, to the rarity of the disease, and the ever growing list of novel therapies that PDT must compete against. These factors make accrual of patients for clinical trials a difficult proposition. During the mid-1990s, a number of reviews were published that effectively summarized the status of PDT for the management of high-grade gliomas. The intent of the present work is to provide an update of recent developments (1996-2004) in PDT and photodynamic detection (PDD) of gliomas, in particular, glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA).
Insights
Photodynamic therapy (PDT) and photodynamic detection (PDD) show promise for treating high-grade gliomas. This review updates recent developments (1996-2004) in these techniques for glioblastoma multiforme and anaplastic astrocytoma.
Area of Science:
- Oncology
- Neurosurgery
- Photomedicine
Background:
- Photodynamic therapy (PDT) was first used for high-grade gliomas in 1981.
- Limited clinical trials have investigated PDT for gliomas due to disease rarity and competition from novel therapies.
- Previous reviews summarized PDT for high-grade gliomas in the mid-1990s.
Purpose of the Study:
- To provide an updated review of recent developments (1996-2004) in PDT and photodynamic detection (PDD) for gliomas.
- To focus on glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA).
Main Methods:
- Literature review of studies published between 1996 and 2004.
- Focus on advancements in PDT and PDD techniques.
- Analysis of clinical trial data and therapeutic efficacy.
Main Results:
- Recent advancements have refined PDT and PDD for glioma treatment.
- The review covers specific progress in managing glioblastoma multiforme and anaplastic astrocytoma.
- Challenges in patient accrual for clinical trials persist.
Conclusions:
- PDT and PDD continue to evolve as therapeutic and diagnostic tools for gliomas.
- Further research and clinical trials are needed to fully establish the efficacy of these modalities.
- Recent developments offer improved options for high-grade glioma management.
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