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Estrogen deficient male mice develop compulsive behavior.

Rachel A Hill1, Kerry J McInnes, Emily C H Gong

  • 1Prince Henry's Institute of Medical Research, Monash University, Clayton, Australia.

Biological Psychiatry
|March 29, 2006
PubMed
Summary
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Estrogen deficiency in aromatase knockout (ArKO) mice leads to compulsive behaviors in males, linked to reduced hypothalamic catechol-O-methyltransferase (COMT) levels. These behaviors and COMT levels normalize with estrogen replacement.

Area of Science:

  • Neuroendocrinology
  • Behavioral Neuroscience
  • Molecular Biology

Background:

  • Aromatase knockout (ArKO) mice are estrogen deficient due to impaired androgen to estrogen conversion.
  • Estrogen plays a crucial role in regulating various physiological processes, including behavior.

Purpose of the Study:

  • To investigate the compulsive behaviors in estrogen-deficient ArKO mice.
  • To examine the relationship between estrogen levels, catechol-O-methyltransferase (COMT) protein levels, and compulsive behaviors.

Main Methods:

  • Analysis of grooming, running wheel activity, and barbering in ArKO and wild-type mice.
  • Measurement of COMT protein levels in frontal cortex, hypothalamus, and liver using Western analysis.
  • Assessment of the effects of 17beta-estradiol replacement therapy.

Related Experiment Videos

Main Results:

  • Male ArKO mice, but not females, exhibited compulsive behaviors (barbering, grooming, wheel-running).
  • These behaviors were reversed by 17beta-estradiol treatment.
  • Hypothalamic COMT protein levels were decreased in male ArKO mice and normalized with estrogen replacement, while frontal cortex and liver COMT levels remained unaffected, indicating tissue-specific regulation.

Conclusions:

  • A novel link between estrogen, COMT, and compulsive behaviors in male mice is identified.
  • Findings suggest potential therapeutic implications for obsessive-compulsive disorder (OCD) patients.