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Related Experiment Videos

Longitudinal changes during aging using proton magnetic resonance spectroscopy.

Amy J Ross1, Perminder S Sachdev, Wei Wen

  • 1School of Psychiatry, University of New South Wales, Sydney, Australia.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|March 29, 2006
PubMed
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Brain metabolite levels, including N-acetyl aspartate, creatine, and choline, remained stable in elderly individuals over three years. Myo-inositol showed a slight increase, but no changes correlated with cognitive function.

Area of Science:

  • Neuroimaging
  • Neurochemistry
  • Gerontology

Background:

  • Proton magnetic resonance spectroscopy ((1)H-MRS) allows non-invasive measurement of brain metabolites.
  • Understanding longitudinal changes in brain metabolites and their relation to cognitive function in aging is crucial.

Purpose of the Study:

  • To investigate the 3-year changes in brain metabolites (N-acetyl aspartate, creatine, choline, myo-inositol) in elderly individuals using (1)H-MRS.
  • To determine the relationship between these metabolite changes and cognitive function over time.

Main Methods:

  • (1)H-MRS and detailed neuropsychological assessments were performed on neurologically normal volunteers (n=40) at baseline and after 3 years.
  • Analyses accounted for age, education, sex, and white matter hyperintensities (WMH).

Related Experiment Videos

  • Metabolites were measured in frontal white matter and occipitoparietal gray matter voxels.

    • Main Results:

    • Most measured metabolites (N-acetyl aspartate, creatine, choline) remained stable over the 3-year period.
    • Frontal myo-inositol levels significantly increased over time, particularly in male participants.
    • No significant changes in neuropsychological performance were observed, and no correlation was found between metabolite changes and cognitive function changes.

    Conclusions:

    • Brain metabolites measured by (1)H-MRS are generally stable in elderly individuals over 3 years.
    • An increase in myo-inositol may indicate aging processes or early neurodegeneration.
    • Observed (1)H-MRS metabolite changes did not correlate with cognitive function changes during this aging period.