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Related Experiment Videos

Pluronic F127: application in arterial embolization.

Shinichi Ohta1, Norihisa Nitta, Masashi Takahashi

  • 1Department of Radiology, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Japan.

Journal of Vascular and Interventional Radiology : JVIR
|March 29, 2006
PubMed
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Pluronic F127, a thermoreversible gel, effectively embolized and dissolved in rabbit arteries within 120 minutes. This temporary embolic agent showed no significant renal or intestinal damage, indicating its potential for medical use.

Area of Science:

  • Biomaterials Science
  • Vascular Interventional Radiology
  • Surgical Research

Background:

  • Pluronic F127 is a thermoreversible polymer widely used in medical and pharmaceutical applications.
  • Its unique property of being liquid below 15°C and gelating between 25-60°C is advantageous for medical procedures.

Purpose of the Study:

  • To evaluate the potential of 20% Pluronic F127 solution as a temporary embolic material.
  • To simulate embolization and dissolution in the renal artery and superior mesenteric artery (SMA) using a rabbit model.

Main Methods:

  • Four rabbits underwent embolization of the renal artery and SMA with 20% Pluronic F127 solution.
  • Embolic effect was assessed via angiography, and pathological changes were evaluated after 24 hours.

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Main Results:

  • Pluronic F127 caused immediate embolization, dissolving within 90-120 minutes in both arteries.
  • No ischemic changes were observed in the renal parenchyma.
  • Focal hemorrhagic changes were noted in the intestine upon dissolution, but no necrosis, suggesting rapid dissolution prevented severe damage.

Conclusions:

  • Pluronic F127 demonstrates potential as a temporary embolic agent.
  • Its rapid dissolution at body temperature minimizes the risk of prolonged tissue ischemia and damage.