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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Basilar-type migraine: clinical, epidemiologic, and genetic features
Malene Kirchmann1, Lise Lykke Thomsen, Jes Olesen
1Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark. kirchmann@dadlnet.dk
Neurology
|March 29, 2006
Summary
Basilar-type migraine (BM) may be a variant of migraine with typical aura (MTA), not a distinct condition. Genetic analysis found no evidence to support BM as a separate entity from MTA.
Area of Science:
- Neurology
- Genetics
- Headache Medicine
Background:
- The classification of basilar-type migraine (BM) as a distinct entity separate from migraine with typical aura (MTA) remains unclear.
- Investigating the phenotype and genotype of BM is crucial for understanding its relationship with MTA.
Purpose of the Study:
- To analyze the clinical symptoms, familial inheritance patterns, and genetic factors associated with basilar-type migraine (BM).
- To determine if BM represents a unique subtype or is part of the spectrum of migraine with typical aura (MTA).
Main Methods:
- Recruited 362 patients from 105 families diagnosed with MTA or BM.
- Sequenced CACNA1A and ATP1A2 genes in 12 BM families with dominant inheritance patterns.
- Performed linkage analysis on chromosomes 1 and 19.
Main Results:
- Basilar-type migraine (BM) occurred in 10% of patients with migraine with typical aura (MTA).
- Common BM symptoms included vertigo, dysarthria, tinnitus, and diplopia.
- No causative mutations or genetic linkage were identified, and BM was equally distributed among families with MTA.
Conclusions:
- Basilar-type aura can occur in patients with migraine with typical aura (MTA).
- Current clinical, epidemiological, and genetic data do not support BM as an independent disease entity distinct from MTA.
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