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Related Experiment Videos

Magnesium therapy in birth asphyxia.

Geeta Gathwala1, Atul Khera, Ishwar Singh

  • 1Department of Paediatrics, Pt BDS PGIMS, Rohtak, India. g_gathwala@hotmail.com

Indian Journal of Pediatrics
|March 29, 2006
PubMed
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Magnesium sulfate (MgSO4) administration is safe for newborns with severe birth asphyxia. The achieved serum magnesium levels are within the neuroprotective range, indicating potential for limiting neuronal injury.

Area of Science:

  • Neuroscience
  • Neonatal Medicine
  • Pharmacology

Background:

  • Glutamate-induced neuronal death is a key factor in hypoxic-ischemic brain injury.
  • N-methyl D-aspartate (NMDA) receptors play a critical role in delayed neuronal death.
  • Magnesium (Mg) is an NMDA receptor antagonist with demonstrated neuroprotective effects in animal models.

Purpose of the Study:

  • To evaluate the safety and efficacy of magnesium sulfate (MgSO4) administration in term neonates with severe birth asphyxia.
  • To determine if MgSO4 infusion results in serum Mg levels within the neuroprotective range.
  • To assess the impact of MgSO4 on vital signs in neonates.

Main Methods:

  • A randomized controlled trial involving 40 neonates with severe birth asphyxia (Apgar scores <3 at 1 min, <6 at 5 min).

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  • Study group received intravenous MgSO4 (250 mg/kg loading dose, followed by 125 mg/kg at 24 and 48 hours).
  • Control group received standard care; serum Mg levels and vital signs were monitored.

    • Main Results:

    • Serum Mg levels in the study group were significantly higher than controls (p<0.001) and ranged from 1.493 to 1.916 mmol/L.
    • These levels are considered within the neuroprotective range.
    • No significant alterations in heart rate, respiratory rate, oxygen saturation, or mean arterial pressure were observed.

    Conclusions:

    • Intravenous MgSO4 administration at the studied doses (250 mg/kg and 125 mg/kg) is safe in neonates with severe birth asphyxia.
    • The achieved serum Mg levels are within the neuroprotective range.
    • MgSO4 shows promise as a neuroprotective agent in this vulnerable population.