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Related Experiment Videos

Induced microseizures in West syndrome.

K Otani1, T Tagawa, Y Futagi

  • 1Division of Pediatric Neurology, Osaka Medical Center, Research Institute for Maternal and Child Health, Japan.

Brain & Development
|May 1, 1991
PubMed
Summary

Induced microseizures (IMS) were observed in a 5-month-old girl with West syndrome. These seizures, resembling those in Lennox-Gastaut syndrome, appeared after treatment and resolved upon medication withdrawal.

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Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Neuroscience

Background:

  • West syndrome is a severe infantile epilepsy characterized by infantile spasms.
  • Treatment often involves hormonal therapies and anti-seizure medications.
  • Lennox-Gastaut syndrome shares some EEG and clinical features with West syndrome.

Observation:

  • A 5-month-old girl with symptomatic West syndrome developed new seizure types.
  • These induced microseizures (IMS) occurred after adrenocorticotropic hormone therapy suppressed infantile spasms.
  • The IMS manifested as respiratory irregularities and arrest, eye-opening, and neck extension, correlating with EEG fast wave bursts.

Findings:

  • The observed induced microseizures (IMS) in West syndrome are a novel finding.

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  • These IMS episodes resolved upon discontinuation of clonazepam.
  • The clinical and EEG characteristics of these IMS were similar to those previously reported in Lennox-Gastaut syndrome.

    • Implications:

    • This finding expands the understanding of seizure manifestations in West syndrome.
    • It suggests a potential link or overlap in seizure semiology between West syndrome and Lennox-Gastaut syndrome.
    • Further research is needed to explore the mechanisms and clinical significance of IMS in different epileptic encephalopathies.