Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Type 1 diabetes in Japan.

E Kawasaki1, N Matsuura, K Eguchi

  • 1Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. eijikawa@net.nagasaki-u.ac.jp

Diabetologia
|March 29, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse.

Diabetologia·2013
Same author

Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice.

Clinical and experimental immunology·2013
Same author

CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse.

Apoptosis : an international journal on programmed cell death·2011
Same author

Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset.

Diabetologia·2009
Same author

MEFV mutations in Japanese rheumatoid arthritis patients.

Clinical and experimental rheumatology·2009
Same author

Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders.

Journal of endocrinological investigation·2008

Type 1 diabetes in Japan has low incidence but unique subtypes like slow-onset and fulminant forms. Genetic factors, including MHC and non-MHC genes, influence susceptibility, with distinct patterns compared to Caucasian populations.

Area of Science:

  • Endocrinology
  • Immunology
  • Genetics

Background:

  • Type 1 diabetes results from autoimmune destruction of pancreatic beta cells in genetically predisposed individuals.
  • Incidence and presentation of type 1 diabetes vary significantly by geography and ethnicity.
  • Japan exhibits low type 1 diabetes incidence with distinct subtypes: acute-onset, slow-onset, and fulminant.

Purpose of the Study:

  • To analyze the incidence, prevalence, and subtypes of type 1 diabetes in Japan.
  • To compare genetic associations (MHC and non-MHC genes) of type 1 diabetes in Japanese versus Caucasian populations.
  • To investigate the unique characteristics of fulminant type 1 diabetes in Japan.

Main Methods:

  • Epidemiological analysis of type 1 diabetes incidence and prevalence data in Japan.

Related Experiment Videos

  • Comparative genetic studies examining Human Leukocyte Antigen (HLA) haplotypes and non-MHC gene polymorphisms.
  • Clinical review of type 1 diabetes subtypes, particularly fulminant and slow-onset forms.

    • Main Results:

    • Type 1 diabetes incidence in Japanese children (0-14 years) increased from 1973-1992 but stabilized recently.
    • Adult-onset type 1 diabetes prevalence is more than double that of childhood-onset, with two-thirds presenting as slow-onset.
    • Distinct HLA haplotype associations are observed, with protective haplotypes common in Japanese patients, unlike Caucasian populations.
    • Shared non-MHC susceptibility genes (INS, CTLA4, IL18, MICA) are implicated in both Japanese and Caucasian type 1 diabetes.

    Conclusions:

    • Type 1 diabetes in Japan presents with unique epidemiological and genetic features, including a high prevalence of slow-onset and fulminant subtypes in adults.
    • Genetic susceptibility to type 1 diabetes in Japan involves different HLA profiles and shared non-MHC gene polymorphisms compared to Caucasian populations.
    • Further research is needed to elucidate the pathogenesis of beta cell destruction and the environmental factors influencing type 1 diabetes subtypes in Japan.