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[Study on the anti-cerebral ischemia/reperfusion injury effect and it's mechanisms of HD02]
Danyang Zhao1, Mingqi Zhao, Weikang Wu
1Guangzhou Children's Hospital, Guangzhou.
Objective:
To study the effect of HD02 on Anti-Cerebral Ischemia/Reperfusion Injury.
Methods:
The mice cerebral Ischemia/Reperfusion models were randomly divided into three group: control group, I/R group and treating groups (different dosages of HD02). At the end of the experiment, brain tissues were harvested to measure the brain water content, SOD activity, MDA content and the activity of Na+/K+ -ATP and Ca2+ -ATP enzyme.
Results:
HD02 could obviously decrease the brain water content (P < 0.01) and the MDA content ( P < 0.01), while, it could also, increase the activity of SOD (P < 0.01) and the activity of ATP enzyme (P < 0.05). These data showed that there was sever oxidative damage in brain tissue and HD02 could prevent I/R injury in brain.
