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Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis
1Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, Palo Alto, California 94301.
Antimicrobial Agents and Chemotherapy
|August 1, 1991
Abstract:
A dose of 75 mg of azithromycin per kg of body weight per day combined with a dose of 2 micrograms of gamma interferon per day and administered for 10 days protected at least 40% of mice infected with a lethal inoculum of Toxoplasma gondii. Azithromycin administered alone protected less than 10% of the mice; gamma interferon had no protective effect.