[Polyenzymatic therapy in prevention of adhesive processes in the abdominal cavity in children]

Area of Science:

• Gastroenterology
• Pediatric Surgery
• Immunology

Background:

• Adhesive intestinal obstruction is a common complication after abdominal surgery in children, particularly following appendectomy.
• Inflammatory processes and cytokine imbalances play a crucial role in the development of post-operative complications, including intra-abdominal adhesions.

Purpose of the Study:

• To evaluate the efficacy of polyenzyme preparations in managing acute adhesive intestinal obstruction and inflammatory responses in children post-appendectomy.
• To analyze the impact of Wobenzym and Hyaluronidase on cytokine profiles in pediatric patients.

Main Methods:

• A clinical investigation involving 48 pediatric patients with acute adhesive intestinal obstruction post-appendectomy.
• Patients were divided into a polyenzyme group (Wobenzym) and a monoenzyme group (Hyaluronidase).
• Cytokine status analysis was performed on 34 children with acute phlegmonous appendicitis.

Main Results:

• The polyenzyme group (Wobenzym) experienced no postoperative complications, whereas the monoenzyme group (Hyaluronidase) had 2 cases of intestinal obstruction.
• Wobenzym significantly reduced pro-inflammatory cytokines (IL-2, IL-6, TNF-alpha) and increased the anti-inflammatory cytokine (IL-4).
• Polyenzyme preparations demonstrated a reduction in intra-abdominal adhesions and inflammatory processes.

Conclusions:

• Polyenzyme preparations, such as Wobenzym, are beneficial in preventing postoperative complications and reducing inflammation after abdominal surgery in children.
• Wobenzym effectively modulates the immune response by altering pro- and anti-inflammatory cytokine levels.
• The use of polyenzymes is recommended for managing intra-abdominal adhesions and inflammatory conditions in pediatric surgical patients.