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Updated: Jul 23, 2026

Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae
11:06

Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae

Published on: December 29, 2017

Histone post-translational modifications regulate transcription and silent chromatin in Saccharomyces cerevisiae

N C Tolga Emre1, S L Berger

  • 1Gene Expression & Regulation Program, The Wistar Institute, Philadelphia, PA 19104, USA.

Ernst Schering Research Foundation Workshop
|March 30, 2006
PubMed

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Histone Modification02:32

Histone Modification

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Acetylation
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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
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Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
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Eukaryotic Transcription Inhibitors

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Histone Modification

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