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Micelles

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

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Updated: Jun 29, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Multifunctional polymeric nanoparticles from diverse bioactive agents.

Paul A Bertin¹, Julianne M Gibbs, Clifton Kwang-Fu Shen

¹Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.

Journal of the American Chemical Society

|March 30, 2006

Summary

This summary is machine-generated.

Researchers developed multifunctional polymeric nanoparticles (PNPs) for targeted drug delivery. These nanoparticles can carry DNA, proteins, or drugs and are internalized by breast cancer cells, showing promise for cancer therapy.

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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Area of Science:

Biomaterials Science
Nanotechnology
Polymer Chemistry

Background:

Developing targeted drug delivery systems is crucial for effective cancer therapy.
Polymeric nanoparticles (PNPs) offer a versatile platform for encapsulating and delivering bioactive agents.
Internalization by cancer cells is a key step for therapeutic efficacy.

Purpose of the Study:

To create multifunctional polymeric nanoparticles (PNPs) capable of delivering diverse bioactive agents.
To enable the surface functionalization of PNPs with targeting moieties like antibodies.
To demonstrate the internalization of these functionalized PNPs by human breast cancer cells.

Main Methods:

Utilized ring-opening metathesis polymerization (ROMP) to synthesize block copolymers.
Incorporated drug molecules (>50% w/w) and tosylated hexaethylene glycol segments into copolymers.
Assembled block copolymers into core-shell PNPs and conjugated DNA and/or antibodies to the surface.

Main Results:

Successfully prepared drug-loaded block copolymers via ROMP.
Assembled copolymers into core-shell PNPs with high drug content.
Demonstrated efficient surface conjugation of DNA and antibodies.
Showcased significant uptake of antibody-functionalized PNPs by antigen-overexpressing breast cancer cells.

Conclusions:

A rational method for creating multifunctional polymeric nanoparticles was established.
These PNPs can be tailored for targeted delivery of various bioactive agents.
The developed nanoparticles show potential for targeted cancer therapy due to efficient cellular uptake.