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Published on: February 4, 2014
Nematode neuropeptide receptors and their development as anthelmintic screens
K Greenwood1, T Williams, T Geary
1Pfizer Animal Health, Ramsgate Road, Sandwich, Kent CT13 9NJ. karen.g.greenwood@pfizer.com
Parasitology
|March 30, 2006
Abstract:
This review addresses the potential use of neuropeptide receptors for the discovery of anthelmintic agents, and particularly for the identification of non-peptide ligands. It outlines which nematode neuropeptides are known and have been characterized, the published information on drug discovery around these targets, information about existing high- and low-throughput screening systems and finally the likely safety of neuropeptide mimetics.
