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Huntington's Disease.

Donald S Higgins1

  • 1Parkinson's Disease and Movement Disorders Center, Albany Medical College, 215 Washington Avenue Extension, Albany, NY 12205, USA. higgind@mail.amc.edu

Current Treatment Options in Neurology
|March 30, 2006
PubMed
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Current Huntington's disease (HD) treatments manage symptoms like movement disorders and psychosis. Future research into neurodegeneration mechanisms promises revolutionary therapies for HD management.

Area of Science:

  • Neurology
  • Pharmacology
  • Rehabilitation Medicine

Background:

  • Huntington's disease (HD) presents complex motor, cognitive, and psychiatric symptoms.
  • Available treatments offer symptomatic relief but do not halt disease progression.

Purpose of the Study:

  • To review current therapeutic strategies for managing Huntington's disease symptoms.
  • To highlight the role of pharmacological and non-pharmacological interventions.
  • To discuss future directions in HD treatment.

Main Methods:

  • Review of existing literature on Huntington's disease treatments.
  • Analysis of pharmacological agents targeting hyperkinetic movements, psychosis, mood disorders, and dementia.
  • Evaluation of the role of rehabilitation services.

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Main Results:

  • Dopamine antagonists and other agents can control hyperkinetic movements and psychosis.
  • Antidepressants, particularly SSRIs, effectively manage mood and behavioral disturbances.
  • Cholinesterase inhibitors show potential for improving cognitive function in advanced HD.
  • Physical, occupational, and speech therapy are crucial for managing diverse symptoms.

Conclusions:

  • Symptomatic management of Huntington's disease significantly improves quality of life.
  • A multidisciplinary approach combining pharmacotherapy and rehabilitation is essential.
  • Understanding neurodegeneration mechanisms is key to developing disease-modifying therapies.