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Morganella morganii pericarditis 3 years after allogenic bone marrow transplantation for mantle cell lymphoma

Zhi-Tao Yang1, Marc Lecuit, Felipe Suarez

  • 1Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades Hospital, René Descartes Paris-5 University Medical School, Paris, France.

The Journal of Infection
|March 30, 2006
PubMed

Insights

A rare case of acute purulent pericarditis caused by Morganella morganii occurred 3 years after bone marrow transplantation. Successful treatment involved drainage and antibiotics, highlighting M. morganii as a cause of pericarditis in immunocompromised patients.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Transplantation Immunology

Background:

  • Allogeneic bone marrow transplantation (BMT) is a complex procedure with potential long-term complications.
  • Immunosuppression and splenectomy are common in BMT recipients, increasing susceptibility to infections.
  • Purulent pericarditis is a serious but uncommon infection of the pericardium.

Observation:

  • A patient developed acute purulent pericarditis three years post-allogeneic bone marrow transplantation.
  • The causative agent identified was Morganella morganii.
  • The patient had undergone splenectomy and was on immunosuppression for chronic graft-versus-host disease (GVHD).

Findings:

  • Morganella morganii was successfully treated with surgical drainage and a six-week course of cefotaxime.
  • The patient's history of splenectomy and immunosuppression for chronic GVHD were identified as likely predisposing factors.
  • This case suggests M. morganii as a potential pathogen in post-BMT purulent pericarditis.

Implications:

  • M. morganii should be recognized as a cause of purulent pericarditis, particularly in immunocompromised individuals.
  • Clinicians should consider M. morganii in the differential diagnosis of pericarditis in BMT recipients.
  • This case underscores the importance of vigilance for opportunistic infections in long-term BMT survivors.

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