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Risperidone treatment of bipolar mania
Lisa N Nguyen1, Sally K Guthrie
1Primary Care Pharmacy Department, Providence Medical Group, Beaverton, OR, USA.
The Annals of Pharmacotherapy
|March 30, 2006
Summary
Risperidone effectively treats bipolar mania symptoms in adults, with potential side effects like somnolence and weight gain. Further research is needed for severe mania and maintenance treatment.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Trials
Background:
- Bipolar mania requires effective treatment options.
- Risperidone is an atypical antipsychotic used in psychiatric care.
- Evidence for risperidone's efficacy in bipolar mania needs comprehensive review.
Purpose of the Study:
- To review clinical trial evidence on risperidone's efficacy and safety for bipolar mania.
- To assess risperidone's effectiveness in monotherapy and combination therapy.
Main Methods:
- Searched PubMed, EMBASE, and International Pharmaceutical Abstracts (1970-August 2005).
- Included six randomized trials and six observational studies.
- Focused on clinical trials for efficacy and safety data.
Main Results:
- Risperidone monotherapy reduced manic symptoms (Young Mania Rating Scale scores) in moderate mania.
- Common side effects included somnolence, extrapyramidal symptoms (EPS), and weight gain.
- Combination therapy with mood stabilizers also decreased manic symptoms in moderate to severe mania.
Conclusions:
- Risperidone monotherapy or adjunctive therapy shows potential for acute bipolar mania in adults with moderate severity.
- Efficacy in severe mania and for maintenance treatment requires further investigation.
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