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Effect of glucosamine on glucose control
1University of Michigan Health System and College of Pharmacy, Ann Arbor, MI 48109, USA. jlstumpf@umich.edu
The Annals of Pharmacotherapy
|March 30, 2006
Summary
Glucosamine supplementation appears safe for glucose control in short-term studies. However, long-term effects, especially in individuals with diabetes mellitus, require further investigation and monitoring.
Area of Science:
- Pharmacology and Metabolism
- Endocrinology
Background:
- Glucosamine is a popular dietary supplement.
- Concerns exist regarding its potential impact on glucose metabolism and insulin resistance.
Purpose of the Study:
- To conduct a literature review on the effects of glucosamine on glucose control.
- To evaluate the safety of glucosamine supplementation for individuals with and without diabetes mellitus.
Main Methods:
- Systematic literature search of MEDLINE, EMBASE, and International Pharmaceutical Abstracts.
- Review of English-language articles from 1966 to March 2006.
- Screening of abstracts and bibliographies for relevant studies on glucosamine and glucose control.
Main Results:
- Animal studies suggest potential insulin resistance with intravenous glucosamine, but this is not confirmed in humans.
- No significant alterations in glucose control observed in human studies with oral glucosamine for osteoarthritis or in short-term trials.
- Long-term effects of glucosamine in diabetic patients remain largely unestablished.
Conclusions:
- Short-term use of glucosamine may be acceptable for selected patients without impacting glucose control.
- Limited data exists for diabetic populations, necessitating careful monitoring for glucose level changes.
- Further well-controlled trials are needed to establish long-term safety in patients with diabetes mellitus.