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Adiponectin and cancer: a systematic review
I Kelesidis1, T Kelesidis, C S Mantzoros
1Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
British Journal of Cancer
|March 30, 2006
Summary
Obesity increases cancer risk. This review explores how adiponectin, a protein linked to metabolism, influences obesity-related cancers and their molecular mechanisms.
Area of Science:
- Endocrinology
- Oncology
- Metabolic Syndrome
Background:
- Obesity is a known risk factor for various cancers.
- The precise molecular links between obesity and cancer development require further investigation.
Purpose of the Study:
- To review current findings on the association between adiponectin and malignancies.
- To explore the molecular mechanisms linking obesity, adiponectin, and cancer risk.
Main Methods:
- Literature review of recent studies.
- Analysis of molecular pathways involved in adiponectin signaling.
- Synthesis of data on adiponectin's role in obesity-related cancers.
Main Results:
- Adiponectin, an adipocyte-secreted protein, influences glucose and lipid metabolism.
- Emerging evidence suggests adiponectin plays a role in the development and progression of obesity-related cancers.
- Specific molecular mechanisms underlying this association are being elucidated.
Conclusions:
- Adiponectin is a key mediator in the relationship between obesity and cancer.
- Understanding these mechanisms offers novel insights into cancer prevention and treatment strategies.
- Further research is needed to address remaining questions regarding adiponectin's role in oncogenesis.