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Updated: Aug 9, 2026

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
Published on: November 25, 2025
Frameless stereotactic subcaudate tractotomy for intractable obsessive-compulsive disorder
P A Woerdeman1, P W A Willems, H J Noordmans
1Department of Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center-Utrecht, The Netherlands. p.a.woerdeman@neuro.azu.nl
Abstract:
Obsessive-compulsive disorder (OCD) is a chronic, disabling disorder. Psychosurgery may be indicated for a subset of patients for whom no conventional treatment is satisfactory. This paper focuses on the stereotactic subcaudate tractotomy (SST). Thus far, these procedures have been carried out using frame-based stereotactic techniques. However, modern - highly accurate - frameless stereotactic procedures have successfully been introduced in neurosurgical practice. We developed a novel frameless stereotactic subcaudate tractotomy procedure with promising initial results in a patient suffering from intractable OCD. This is the first report on frameless SST. Future studies should examine whether other ablative stereotactic psychosurgery procedures can be done using frameless stereotactic methods.
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