Related Experiment Video
Updated: Aug 9, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Bladder dysfunction in Parkinsonism: mechanisms, prevalence, symptoms, and management
Kristian Winge1, Clare J Fowler
1Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark. k.winge@dadlnet.dk
Summary
Dopamine receptor dysfunction significantly impacts bladder control, leading to overactive bladder symptoms common in Parkinsonism. Addressing these non-motor symptoms is crucial for patient management.
Area of Science:
- Neuroscience
- Urology
Background:
- Functional imaging advances understanding of neural bladder control.
- Dopaminergic mechanisms are critical for normal urinary function.
Purpose of the Study:
- Review current concepts of brain function in urinary control.
- Emphasize the role of dopamine receptors in bladder control.
- Highlight overlooked non-motor bladder dysfunction in Parkinsonism.
Main Methods:
- Literature review of functional imaging studies.
- Analysis of research on dopaminergic pathways and bladder control.
- Examination of clinical presentations of bladder dysfunction in Parkinsonism and multiple-system atrophy.
Main Results:
- Dopamine receptor dysfunction is linked to overactive bladder symptoms.
- High prevalence of nocturia, frequency, and urgency in Parkinson's disease.
- Complex bladder complaints in multiple-system atrophy include urge incontinence and poor emptying.
Conclusions:
- Dopaminergic mechanisms are key to normal bladder function.
- Bladder dysfunction is a significant non-motor symptom in Parkinsonism.
- Management requires addressing overactive detrusor and incontinence.
Related Concept Videos
01:24Parkinson's Disease: Treatment
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
01:24Parkinson Disease l: Introduction
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
01:15Parkinson's Disease: Overview
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
01:24Parkinson Disease ll: Pathophysiology
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
01:11Alterations in Muscle Tone lll
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
01:20Disorders of the Urinary System
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...