Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal interactions with the extracellular matrix.

I de Curtis1

  • 1Howard Hughes Medical Institute, University of California, San Francisco.

Current Opinion in Cell Biology
|October 1, 1991
PubMed
Summary

Neurons interact with extracellular matrix cues to form precise nervous system networks. This review explores the molecular machinery driving these crucial neuronal development interactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The α6β1 integrin is a laminin receptor for developing retinal neurons.

Cytotechnology·2012
Same author

Liprin-α1 regulates breast cancer cell invasion by affecting cell motility, invadopodia and extracellular matrix degradation.

Oncogene·2010
Same author

Molecular mechanisms regulating the subcellular localization of p95-APP1 between the endosomal recycling compartment and sites of actin organization at the cell surface.

Journal of cell science·2002
Same author

Cell migration: GAPs between membrane traffic and the cytoskeleton.

EMBO reports·2001
Same author

p95-APP1 links membrane transport to Rac-mediated reorganization of actin.

Nature cell biology·2000
Same author

Estradiol induces differential neuronal phenotypes by activating estrogen receptor alpha or beta.

Endocrinology·2000

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Neuronal network formation is critical for nervous system development.
  • Extracellular cues play a vital role in guiding neuronal development.
  • Understanding these interactions is key to deciphering neural circuit assembly.

Purpose of the Study:

  • To review recent advancements in understanding neuronal interactions with the extracellular matrix.
  • To highlight the molecular mechanisms governing neuron-extracellular matrix crosstalk.
  • To provide insights into the molecular machinery directing neuronal network formation.

Main Methods:

  • Literature review of recent research.
  • Analysis of studies on molecular components involved in neuron-extracellular matrix interactions.
  • Synthesis of findings on developmental processes.

Main Results:

  • Identified key molecular players mediating neuron-extracellular matrix interactions.
  • Detailed the mechanisms by which extracellular matrix components influence neuronal guidance and network formation.
  • Highlighted the dynamic nature of these interactions during development.

Conclusions:

  • The molecular machinery governing neuron-extracellular matrix interactions is complex and multifaceted.
  • Precise neuronal network formation relies heavily on these dynamic cellular interactions.
  • Further research into these mechanisms can inform therapeutic strategies for neurological disorders.

Related Experiment Videos