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[Study on reflux esophagitis treated by Tongjiang granule].
Xu-Dong Tang1, Hong-Mei Wu, Zhi-Bin Wang
1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. txdly@sina.com.cn
Summary
Tongjiang granule effectively treats gastroesophageal reflux disease (GERD) by reducing stomach acid and increasing blood motilin. This traditional Chinese medicine shows promise in improving gastric motility and alleviating GERD symptoms.
Area of Science:
- Gastroenterology
- Pharmacology
- Traditional Chinese Medicine
Context:
- Gastroesophageal reflux disease (GERD) is a prevalent condition requiring effective treatment options.
- Understanding the mechanistic basis of traditional remedies like Tongjiang granule is crucial for evidence-based medicine.
Purpose:
- To elucidate the therapeutic mechanism of Tongjiang granule in a rat model of GERD.
- To compare the efficacy of Tongjiang granule with a conventional GERD medication, perpulsid.
Summary:
- Tongjiang granule administration in a GERD rat model led to reduced esophageal lesions and gastric acid levels.
- Treatment with Tongjiang granule increased circulating motilin levels, suggesting a role in enhancing gastrointestinal motility.
- The study demonstrated that Tongjiang granule was more effective than perpulsid in ameliorating GERD pathology in this experimental model.
Impact:
- Provides mechanistic insights into the efficacy of Tongjiang granule for GERD.
- Supports the potential of Tongjiang granule as a therapeutic agent for GERD.
- Highlights the importance of motilin modulation in GERD treatment.