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Published on: August 15, 2016
Experimental study on stability of a high-porosity expanded polytetrafluoroethylene graft in dogs
Mitsuhiro Isaka1, Toshiya Nishibe, Yasuhiro Okuda
1Department of Cardiovascular Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
Purpose:
The purpose of the present study was to evaluate the stability of a high-porosity expanded polytetrafluoroethylene (ePTFE) graft, which has been shown to possess excellent biocompatibility and tissue integration.
Methods:
The graft used in the present study was a high-porosity ePTFE graft , which had an average internodal distance of approximately 60 microm and a random node architecture with tortuous path channels extending from the outer to the inner surface. Eleven beagle dogs (each group n = 3 or 4) weighing 10-12 kg were used. The graft, with a 6 mm inside diameter and a 30-40 mm length, was implanted into the canine abdominal aorta and retrieved after 2-80 weeks. The deformation of the graft was evaluated by conventional computed tomography (CT). The radial tensile strength, longitudinal tensile strength, and suture retention strength of the graft were measured after 2-80 weeks.
Results:
CT studies showed no anastomotic aneurysm or deformation of the graft. Physical tests demonstrated no significant deterioration in suture retention strength, radial tensile strength or longitudinal tensile strength for periods ranging from 2-80 weeks compared to pre-implantation grafts.
Conclusion:
The graft possesses adequate stability that ensures safe and effective clinical use.
