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Related Experiment Videos

Single breath-hold T1 measurement using low flip angle TrueFISP.

L Bokacheva1, A J Huang, Q Chen

  • 1Department of Radiology, New York University School of Medicine, New York, New York 10016, USA.

Magnetic Resonance in Medicine
|March 31, 2006
PubMed
Summary

This study introduces a fast T1 mapping method using segmented inversion recovery TrueFISP (sIR-TrueFISP) for single breath-hold scans. The technique accurately measures T1 values in phantoms and human tissues, proving valuable for abdominal and chest imaging.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Medical Physics

Background:

  • Accurate T1 quantification is crucial for various MRI applications, including tissue characterization and contrast agent assessment.
  • Traditional T1 mapping techniques often require long acquisition times, limiting their clinical utility, especially in abdominal and thoracic imaging due to respiratory motion.

Purpose of the Study:

  • To develop and validate a novel, rapid T1 estimation method using a single breath-hold, segmented inversion recovery prepared, true fast imaging with steady-state precession (sIR-TrueFISP) acquisition.
  • To compare the accuracy and reliability of the proposed sIR-TrueFISP technique against a standard T1 mapping method.

Main Methods:

  • Implementation of a low flip angle (FA) sIR-TrueFISP sequence for T1 mapping.

Related Experiment Videos

  • Acquisition of T1 measurements in a Gd-DTPA-doped water phantom and in the brain and abdomen of healthy volunteers.
  • Comparison of sIR-TrueFISP derived T1 values with those obtained using the conventional inversion recovery fast spin echo (IR-FSE) technique.

    • Main Results:

    • Excellent correlation (R²=0.999) between sIR-TrueFISP and IR-FSE in the phantom.
    • Good correlation (R²=0.943) between the two methods in human brain and abdominal tissues.
    • T1 values obtained using sIR-TrueFISP were in good agreement with previously published data.

    Conclusions:

    • The sIR-TrueFISP technique provides accurate T1 measurements within a single breath-hold.
    • This rapid T1 mapping method is highly suitable for clinical applications, particularly for imaging organs affected by physiological motion such as the chest and abdomen.