Genetic difference in sensitivity to beta-carboline: evidence for the involvement of brain benzodiazepine receptors
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G Chapouthier1, D Bondoux, B Martin
1Génétique, Neurogénétique et Comportement, U.R.A. C.N.R.S. 1294, Université Paris V, France.
Brain Research
|July 12, 1991
Abstract:
The convulsive effects of methyl beta-carboline-3-carboxylate (beta-CCM), a benzodiazepine receptor ligand, are different in two inbred strains of mice: BALB/cBy mice are more sensitive to beta-CCM than C57BL/6J mice. In the present article, we report the effects of [3H]flunitrazepam binding in these two strains, which suggest a possible explanation of the differences in their sensitivity to beta-CCM by the involvement of brain benzodiazepine receptors.