Related Experiment Video
Updated: Aug 9, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
Published on: November 29, 2024
[The experimental study of mechanism of integrin in hypertrophic scar contracture]
Zheng-yu He1, Xiao-bing Hou, Zhi-hong Fan
1Department of Plastic Surgery, Renji Hospital, SSMV, Shanghai 200127, China.
Objective:
To study the mechanism of integrin in hypertrophic scar.
Methods:
Fibroblasts from 10 samples of human hypertrophic scars was cultured, FQ-PCR assay was applied to detect mRNA expression of alpha-SMA in hypertrophic scar fibroblasts after integrin and FAK antibody blocking.
Results:
mRNA of alpha-SMA in fibroblasts expressed obviously lower after integrin and FAK antibody blocking than that of control groups ( P < 0.05).
Conclusion:
Through accelerating the synthesis of alpha-SMA, integrin and FAK play an important role in contracture of hypertrophic scar.
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