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Crusted scabies: a clinical review
Kjetil Kristoffer Guldbakke1, Amor Khachemoune
1International Training Program, Harvard Medical School, Boston, MA, USA.
Abstract:
Crusted scabies, a rare variant of classical scabies, is a highly contagious condition in which the skin is infected with thousands to millions of mites. It can be defined as a generalized severe scabies infestation usually affecting immunocompromised patients. The diagnosis is becoming more relevant with the increasing use of immunosuppressive medications and the HIV epidemic. To date, more than 200 cases have been reported in the literature. We present a review of the pathogenesis, clinical manifestations, diagnostic considerations, and therapeutic options.
Insights
Crusted scabies is a severe, contagious skin infestation by mites, often seen in immunocompromised individuals. Its relevance is increasing due to immunosuppressive drugs and the HIV epidemic.
Area of Science:
- Dermatology
- Infectious Diseases
- Parasitology
Background:
- Crusted scabies is a severe form of scabies infestation.
- It typically affects immunocompromised patients.
- The condition is becoming more prevalent due to increased immunosuppression and the HIV epidemic.
Purpose of the Study:
- To review the pathogenesis of crusted scabies.
- To outline the clinical manifestations.
- To discuss diagnostic and therapeutic strategies.
Main Methods:
- Literature review of published cases and research.
- Analysis of existing data on pathogenesis, clinical presentation, diagnosis, and treatment.
Main Results:
- Crusted scabies involves millions of mites, leading to generalized, severe skin lesions.
- Diagnosis is crucial, especially in at-risk populations.
- Over 200 cases have been documented.
Conclusions:
- Crusted scabies requires prompt recognition and management.
- Understanding its pathogenesis aids in developing effective treatments.
- This review provides a comprehensive overview for clinicians.
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