Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA microarray and proteomic strategies for understanding alcohol action.

James M Sikela1, Erik J Maclaren, Young Kim

  • 1University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, USA.

Alcoholism, Clinical and Experimental Research
|April 1, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial.

JAMA·2026
Same author

A quantitative proteomics dataset for assessment and prediction of low dose X-ray radiation exposure in mice.

bioRxiv : the preprint server for biology·2026
Same author

Serum proteomics reveals distinct phenotypic signatures to IL-6 blockade between two immunotherapies.

bioRxiv : the preprint server for biology·2026
Same author

Circulating miRNA-Protein Signatures Predict Outcomes in Pediatric Dilated Cardiomyopathy.

bioRxiv : the preprint server for biology·2026
Same author

Age-dependent Transcriptional Programs Distinguish Pediatric from Adult Dilated Cardiomyopathy.

medRxiv : the preprint server for health sciences·2026
Same author

Engaging Gut-to-Brain Signalling to Treat Alcohol Use Disorder.

Addiction biology·2026

This symposium explored gene copy number variation and brain gene expression to understand the genetic basis of alcohol action and related traits. Research utilized genomewide surveys and proteomic analysis in mice models.

Area of Science:

  • Genetics
  • Neuroscience
  • Alcohol Research

Background:

  • The genetics of alcohol action and alcohol-related traits are complex and influenced by numerous genes.
  • Understanding gene copy number variation (CNV) and regional gene expression differences in the brain is crucial for identifying these genes.

Framework:

  • This symposium summarized research presented at the 2005 Research Society on Alcoholism annual meeting.
  • Presentations focused on novel approaches to investigate the genetic underpinnings of alcohol effects.

Implementation:

  • Genomewide surveys of gene copy number variation (CNV) in humans and mice were discussed.
  • Regional differences in brain gene expression were analyzed for relevance to alcohol-related traits.
  • Expression profiling in congenic mice (Inbred Long Sleep/Inbred Short Sleep) was used to identify ethanol quantitative trait loci (QTL) candidate genes.

Related Experiment Videos

  • Quantitative proteomic analysis was performed on AC7-modified mice.

    • Implications:

    • These studies highlight the importance of genomic and proteomic approaches in unraveling the genetic architecture of alcohol dependence and related phenotypes.
    • Identifying specific genes and pathways involved in alcohol action can pave the way for targeted interventions.
    • The research underscores the utility of animal models in genetic studies of complex traits.