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Skin changes in pediatric transplant patients
Ana Paula Dornelles da Silva Manzoni1, Ricardo Lapa Kruse, Carina Troian
1Department of Dermatology of Hospital de Clínicas de Porto Alegre, RS, Brazil. apdsmanzoni@terra.com.br
Pediatric Transplantation
|April 1, 2006
Summary
Pediatric organ transplant recipients experience unique skin changes, often linked to medications. This study highlights specific dermatological conditions in kidney, liver, and bone marrow transplant patients, emphasizing age-related differences.
Area of Science:
- Dermatology
- Pediatric Medicine
- Transplantation
Background:
- Organ transplantation has introduced new disease categories, including transplant-associated dermatoses.
- Pediatric transplant recipients require specific consideration due to age-related factors distinct from adults.
Purpose of the Study:
- To investigate the spectrum and frequency of cutaneous alterations in pediatric organ transplant recipients.
- To identify unique dermatological manifestations in children undergoing kidney, liver, or bone marrow transplantation.
Main Methods:
- A prospective cohort study of 39 pediatric patients (up to 17 years) undergoing kidney, liver, or bone marrow transplant (BMT) in Porto Alegre, Brazil.
- Regular skin examinations were conducted for six months post-transplant.
- An incidence density (ID) was calculated to quantify skin changes.
Main Results:
- Medication use was the primary cause of skin changes (87.2%).
- Kidney transplant recipients showed the highest medication-related skin change ID (104.1).
- BMT recipients had the highest ID of skin appendage alterations (85.4), and liver transplant recipients had the highest ID of vascular changes (94.9).
Conclusions:
- Pediatric transplant recipients exhibit distinct cutaneous alterations compared to adults, including ichthyosiform xerosis in renal recipients and pellagroid skin scaling in BMT recipients.
- Medication-induced dermatoses are the predominant finding in this pediatric population.