Leukemia attributable to residential magnetic fields: results from analyses allowing for study biases

Nearly every epidemiologic study of residential magnetic fields and childhood leukemia has exhibited a positive association. Nonetheless, because these studies suffer from various methodologic limitations and there is no known plausible mechanism of action, it remains uncertain as to how much, if any, of these associations are causal. Furthermore, because the observed associations are small and involve only the highest and most infrequent levels of exposure, it is believed that the public health impact of an effect would be small. We present some formal analyses of the impact of power-frequency residential magnetic-field exposure (as measured by attributable fractions), accounting for our uncertainties about study biases as well as uncertainties about exposure distribution. These analyses support the idea that the public health impact of residential fields is likely to be limited, but both no impact and a substantial impact remain possibilities in light of the available data.