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Updated: Aug 9, 2026
Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods
Published on: June 25, 2019
Multiple components of the defense response depend on orexin: evidence from orexin knockout mice and orexin
Wei Zhang1, Megumi Shimoyama, Yasuichiro Fukuda
1Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, 1-8-1 Chuo-ku, Chiba 260-8670, Japan. zhangweijp@graduate.chiba-u.jp
Abstract:
Stressor induces not only cognitive, emotional and behavioral changes but also autonomic changes. Although research on the neural circuits underlying such autonomic changes has implicated the hypothalamus in the defense response against stressors, neurotransmitters in this multifaceted and coordinated response have not been revealed. In this brief review, here we summarize our recent discovery using orexin knockout mice and orexin neuron-ablated mice of possible contribution of orexin in the defense response and discuss future directions.
