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Acral and renal malformations following ICSI
A Schuffner1, L Centa, C Reggiani
1Androlab - Clínica e Laboratório de Reprodução Humana e Andrologia, Curitiba, Brazil. schuffner@androlab.com.br
Archives of Andrology
|April 1, 2006
Summary
Intracytoplasmic sperm injection (ICSI) during in vitro fertilization (IVF) resulted in a baby with limb and renal malformations. Couples undergoing IVF-ICSI-ET should be informed about potential genetic risks.
Area of Science:
- Reproductive Medicine
- Clinical Case Study
- Medical Genetics
Background:
- Assisted reproductive technologies (ART) like in vitro fertilization with intracytoplasmic sperm injection (IVF-ICSI) are widely used for infertility treatment.
- While ART has high success rates, potential risks and complications, including genetic abnormalities, require careful consideration.
Observation:
- A case report details a pregnancy following IVF-ICSI-ET in a couple with primary infertility.
- The couple delivered an infant diagnosed with acrorenal syndrome, characterized by limb and renal malformations.
Findings:
- The infant's malformations are a potential outcome associated with the IVF-ICSI-ET procedure.
- This case highlights a specific instance of congenital anomalies following ART.
Implications:
- Enhanced genetic counseling is crucial for couples considering ART, particularly IVF-ICSI-ET.
- Informed consent processes must thoroughly address the risks of genetic abnormalities and congenital malformations associated with these advanced reproductive techniques.