Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell Size

Cell Size

Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.Surface AreaCells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding the cells limits the...

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

Cell Motility through Blebbing

Cell Motility through Blebbing

Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...

Animal and Plant Cell Structure

Animal and Plant Cell Structure

Animal and plant cells not only differ in their structure, function, and mode of nutrition but also in how they reproduce, specialize, and organize into complex structures.
Cell Division
Though both plant and animal cells divide by mitosis (for non-gametic cells) and meiosis (for gametic cells), they differ in the specifics of this process. Unlike animal cells, plant cells lack centrosomes — an organelle responsible for organizing the spindle fibers and segregating the chromosomes during cell...

Subcellular Fractionation

Subcellular Fractionation

The homogenate obtained after cell lysis contains various membrane-bound organelles that can be further separated into pure fractions by subcellular fractionation. These isolates are used to study specific cellular components, analyze localized protein activity, and are even employed in diagnostics. Fractionation is typically achieved using centrifugation methods, the most common being density-gradient and differential centrifugation.
Differential Centrifugation
Differential centrifugation is...

Cell Inclusions

Cell Inclusions

Prokaryotic cells possess a variety of inclusions that play crucial roles in nutrient storage, metabolic processes, and environmental adaptation. These structures enable bacteria to thrive under fluctuating environmental conditions by storing essential resources and optimizing their metabolic efficiency.Carbon Storage: Poly-β-Hydroxybutyric Acid and Glycogen GranulesBacteria frequently store excess carbon in specialized granules. Poly-β-hydroxybutyric acid (PHB) granules are lipid polymers that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development.

Cell stem cell·2023

Same author

Esrrb Regulates Specific Feed-Forward Loops to Transit From Pluripotency Into Early Stages of Differentiation.

Frontiers in cell and developmental biology·2022

Same author

An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions.

Frontiers in cell and developmental biology·2021

Same author

Memory of Divisional History Directs the Continuous Process of Primitive Hematopoietic Lineage Commitment.

Stem cell reports·2020

Same author

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors.

Journal of visualized experiments : JoVE·2019

Same author

Induction of developmental hematopoiesis mediated by transcription factors and the hematopoietic microenvironment.

Annals of the New York Academy of Sciences·2019

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions

Published on: April 3, 2014

Stem cells and their niches.

Kateri A Moore¹, Ihor R Lemischka

¹Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, NJ 08544, USA. kamoore@princeton.edu

Science (New York, N.Y.)

|April 1, 2006

Summary

This summary is machine-generated.

Stem cell niches coordinate self-renewal and differentiation for continuous cell production. This review highlights progress and questions in intestinal, epidermal, and bone marrow stem cell systems.

More Related Videos

A 3D Cartographic Description of the Cell by Cryo Soft X-ray Tomography

A 3D Cartographic Description of the Cell by Cryo Soft X-ray Tomography

Published on: March 15, 2021

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy

Published on: July 19, 2021

Related Experiment Videos

Last Updated: Jul 8, 2026

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions

Published on: April 3, 2014

A 3D Cartographic Description of the Cell by Cryo Soft X-ray Tomography

A 3D Cartographic Description of the Cell by Cryo Soft X-ray Tomography

Published on: March 15, 2021

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy

Published on: July 19, 2021

Area of Science:

Stem Cell Biology
Cellular Mechanisms
Tissue Homeostasis

Background:

Intrinsic and extrinsic cellular mechanisms regulate stem cell self-renewal and differentiation.
Stem cells, progeny, and microenvironment form anatomical structures for cell production.
Continuous production of mature cells is vital for adult life.

Purpose of the Study:

Discuss the stem cell niche concept.
Highlight recent advancements in stem cell research.
Identify key unanswered questions in the field.

Main Methods:

Review of existing literature on stem cell niches.
Focus on three mammalian stem cell systems: intestinal epithelium, epidermis, and bone marrow.
Analysis of cellular mechanisms governing stem cell behavior.

Main Results:

Stem cell niches are crucial for coordinating cell production.
Significant progress has been made in understanding niche regulation.
Several important questions remain regarding stem cell function and regulation.

Conclusions:

The stem cell niche is a fundamental concept in understanding tissue regeneration.
Further research is needed to fully elucidate the complexities of stem cell niches.
Understanding these systems is critical for regenerative medicine and disease treatment.