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Related Experiment Videos

Splanchnic haemodynamic changes during acute hypoglycaemia in man.

G D Braatvedt1, P G Newrick, M Halliwell

  • 1Department of Medicine, Bristol Royal Infirmary, U.K.

Clinical Science (London, England : 1979)
|October 1, 1991
PubMed
Summary

Hypoglycemia significantly increases splanchnic blood flow and cardiac output in healthy individuals. This response may aid liver gluconeogenesis during blood sugar recovery.

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Area of Science:

  • Physiology
  • Endocrinology
  • Hemodynamics

Background:

  • Insulin-induced hypoglycemia triggers hormonal responses, including increased glucagon, adrenaline, and noradrenaline.
  • Understanding the splanchnic hemodynamic response to hypoglycemia is crucial for metabolic regulation.

Purpose of the Study:

  • To investigate the effects of induced hypoglycemia on splanchnic hemodynamics and cardiac output in healthy subjects.
  • To assess the role of these circulatory changes in the body's homeostatic response to low blood glucose.

Main Methods:

  • Noninvasive Doppler ultrasound was used to measure superior mesenteric artery blood flow and cardiac output.
  • Hypoglycemia was induced intravenously using insulin infusion in seven healthy volunteers.

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Main Results:

  • A significant increase in superior mesenteric artery blood flow (803 ml/min peak) and a decrease in its resistance were observed during hypoglycemia.
  • Cardiac output rose by 33% with a 24% increase in pulse rate, while total peripheral resistance decreased by 21%.
  • These hemodynamic changes occurred alongside a drop in blood glucose to 1.5 mmol/l and hormonal counter-regulation.

Conclusions:

  • Induced hypoglycemia causes substantial increases in splanchnic blood flow and cardiac output.
  • These circulatory adjustments are likely important for hepatic gluconeogenesis and overall metabolic homeostasis during recovery from hypoglycemia.