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Related Concept Videos

Imprinting01:22

Imprinting

Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Managing Impressions01:19

Managing Impressions

Impression management encompasses individuals' deliberate efforts to shape how others perceive them during social interactions. This behavior is often employed to conform to social norms, secure approval, or pursue specific goals. While it involves selective self-presentation, it is not necessarily deceptive; individuals frequently present authentic aspects of themselves that align with situational demands.Common strategies include:Ingratiation: where individuals use flattery or agreeableness...

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Related Experiment Video

Updated: Jul 20, 2026

Nanomoulding of Functional Materials, a Versatile Complementary Pattern Replication Method to Nanoimprinting
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How imprinting centres work.

A Lewis1, W Reik

  • 1Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK. annabelle.lewis@bbsrc.ac.uk

Cytogenetic and Genome Research
|April 1, 2006
PubMed
Summary

Imprinting centers (ICs) control multiple genes through DNA methylation and epigenetic marks. Mechanisms involve CTCF insulators and non-coding RNAs, but their interactions require further study.

Area of Science:

  • Genetics
  • Epigenetics
  • Genomic Imprinting

Background:

  • Imprinted genes are typically located in clusters within the genome.
  • These clusters are often regulated by imprinting centers (ICs), which are differentially methylated in the germline.
  • ICs influence epigenetic marks and gene expression across large genomic distances.

Purpose of the Study:

  • To elucidate the molecular mechanisms by which imprinting centers (ICs) regulate gene clusters.
  • To understand the roles of CTCF-dependent insulators and non-coding RNAs in genomic imprinting.
  • To investigate the interplay of epigenetic marks in establishing and maintaining imprinting.

Main Methods:

  • Analysis of CTCF-dependent insulators and non-coding RNAs in imprinting clusters.

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  • Investigation of higher-order chromatin interactions.
  • Study of DNA methylation and histone modifications associated with imprinting.

    • Main Results:

    • Imprinting centers (ICs) regulate distant genes through mechanisms like enhancer insulation via CTCF.
    • Non-coding RNAs originating from ICs may target histone modifications to neighboring genes.
    • Both DNA methylation and histone modifications are involved, but their hierarchical interactions are unclear.

    Conclusions:

    • CTCF insulators and non-coding RNAs are likely key regulators of imprinting at many loci.
    • Understanding the cascade from germline methylation to lineage-specific imprinting is a critical future challenge.