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Related Experiment Videos

How imprinting centres work.

A Lewis1, W Reik

  • 1Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK. annabelle.lewis@bbsrc.ac.uk

Cytogenetic and Genome Research
|April 1, 2006
PubMed
Summary
This summary is machine-generated.

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Imprinting centers (ICs) control multiple genes through DNA methylation and epigenetic marks. Mechanisms involve CTCF insulators and non-coding RNAs, but their interactions require further study.

Area of Science:

  • Genetics
  • Epigenetics
  • Genomic Imprinting

Background:

  • Imprinted genes are typically located in clusters within the genome.
  • These clusters are often regulated by imprinting centers (ICs), which are differentially methylated in the germline.
  • ICs influence epigenetic marks and gene expression across large genomic distances.

Purpose of the Study:

  • To elucidate the molecular mechanisms by which imprinting centers (ICs) regulate gene clusters.
  • To understand the roles of CTCF-dependent insulators and non-coding RNAs in genomic imprinting.
  • To investigate the interplay of epigenetic marks in establishing and maintaining imprinting.

Main Methods:

  • Analysis of CTCF-dependent insulators and non-coding RNAs in imprinting clusters.

Related Experiment Videos

  • Investigation of higher-order chromatin interactions.
  • Study of DNA methylation and histone modifications associated with imprinting.

    • Main Results:

    • Imprinting centers (ICs) regulate distant genes through mechanisms like enhancer insulation via CTCF.
    • Non-coding RNAs originating from ICs may target histone modifications to neighboring genes.
    • Both DNA methylation and histone modifications are involved, but their hierarchical interactions are unclear.

    Conclusions:

    • CTCF insulators and non-coding RNAs are likely key regulators of imprinting at many loci.
    • Understanding the cascade from germline methylation to lineage-specific imprinting is a critical future challenge.