Preterm delivery of a first child and subsequent mothers' risk of ischaemic heart disease: a nested case-control

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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Olivier Nardi1, Mahmoud Zureik, Dominique Courbon

  • 1INSERM U258, Epidémiologie Cardiovasculaire et Métabolique, Hôpital Paul Brousse, 16 Avenue Paul Vaillant, Couturier 94805, Villejuif, France. oliver.nardi@libertysurf.fr

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
|April 1, 2006
PubMed

Several studies have suggested that preterm delivery is related to a risk of subsequent ischaemic heart disease (IHD) in the mother. We conducted a nested case-control study in the E3N cohort to assess the association between preterm delivery of a first child and IHD, and the effect of major cardiovascular risk factors on this association. The study included 109 cases and 395 controls. Mothers who had preterm delivery were at an increased risk of IHD [multivariate hazard ratio 2.09 (95% confidence interval 1.07-4.09)]. This association was independent of major cardiovascular risk factors.

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