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Optic nerve changes in ocular toxoplasmosis.

G U Eckert1, J Melamed, B Menegaz

  • 1Department of Ophthalmology, Medical School, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Eye (London, England)
|April 1, 2006
PubMed
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Ocular toxoplasmosis commonly affects the optic nerve, often presenting as optic nerve swelling with distant lesions. Most cases were unilateral, with a favorable visual outcome.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Neuro-ophthalmology

Background:

  • Ocular toxoplasmosis is a significant cause of posterior uveitis.
  • Optic nerve involvement can lead to vision loss in ocular toxoplasmosis.

Purpose of the Study:

  • To determine the prevalence and characteristics of optic nerve involvement in ocular toxoplasmosis.
  • To classify different types of optic nerve lesions in this condition.

Main Methods:

  • Retrospective cross-sectional study of patients with active ocular toxoplasmosis.
  • Classification of optic nerve involvement into juxtapapillary retinochoroiditis, papillitis, neuroretinitis, distant, and mixed lesions.

Main Results:

  • Optic nerve involvement occurred in 5.3% of cases.

Related Experiment Videos

  • Optic nerve edema with concurrent distant active lesions was most common (43.1%), followed by juxtapapillary retinochoroiditis (35.3%).
  • Most lesions were unilateral (95.9%), and visual acuity improved in 71.4% of affected eyes.

    • Conclusions:

    • Optic nerve edema with distant active lesions is the most frequent presentation.
    • Juxtapapillary retinochoroiditis is the second most common type of optic nerve lesion.
    • Optic nerve involvement in ocular toxoplasmosis is typically unilateral with a favorable visual prognosis.