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Updated: Aug 9, 2026

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging
Published on: January 5, 2015
Fluorescence of a benzothienopyridopyrimidone in solution and in lipid vesicles
Elisabete M S Castanheira1, Ana M R Pinto, Maria-João R P Queiroz
1Departamento de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal. ecoutinho@fisica.uminho.pt
Abstract:
Fluorescence properties of a biologically active benzothienopyridopyrimidone in solution and in lipid vesicles are reported. Assays at different pH values (0.5-10) allowed the determination of pK(a) = 2.0, showing that this compound may be useful as a pH indicator for pH < or = 4. In lipid vesicles, benzothienopyridopyrimidone locates in a water-rich environment, indicating that it can be carried in the hydrophilic region of liposomes for drug delivery applications.

