Related Experiment Videos
Anastomotic suture materials and experimental colorectal carcinogenesis
J R McGregor1, D J Galloway, F Jarrett
1University Department of Surgery, Western Infirmary, Glasgow, United Kingdom.
Diseases of the Colon and Rectum
|November 1, 1991
Summary
Stainless steel sutures resulted in fewer local colorectal tumors near the anastomosis compared to polyamide or polyglycolic acid sutures in a rat model. This suggests stainless steel may be safe for colorectal cancer surgery.
Area of Science:
- Surgical Oncology
- Gastroenterology
- Experimental Pathology
Background:
- Local tumor recurrence after colorectal cancer surgery can stem from neoplastic lesions near the anastomosis.
- Suture materials used in colorectal surgery may influence perianastomotic tumor development.
Purpose of the Study:
- To compare the impact of stainless steel, polyamide, and polyglycolic acid sutures on colorectal carcinogenesis.
- To evaluate suture material influence on perianastomotic tumor formation in an experimental animal model.
Main Methods:
- Albino Swiss rats underwent tumor induction followed by transmural implantation of different suture materials near the anastomosis.
- A longitudinal colotomy was also created and resutured with the same materials.
- Tumor incidence at perianastomotic and distant sites was assessed 12 weeks post-implantation.
Main Results:
- Stainless steel sutures led to significantly fewer perianastomotic tumors (3/21) compared to polyamide (14/20) and polyglycolic acid (17/21) sutures (P < 0.001).
- Similar results were observed when resuturing a colotomy.
- No significant difference in distant tumor incidence was found based on suture material.
Conclusions:
- Stainless steel staples may promote fewer perianastomotic colorectal tumors than conventional suture materials.
- Stainless steel appears to be a safe option for use in colorectal cancer surgery regarding local recurrence.