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Free radicals from plastic syringes.

G R Buettner¹, B D Scott, R E Kerber

¹Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City 52242.

Free Radical Biology & Medicine

|January 1, 1991

Summary

This summary is machine-generated.

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Disposable sterile plastic syringes can release free radicals into fluids. The observed nitroxide (aminoxyl radical) is identified by its aqueous solution spectrum.

Area of Science:

Chemistry
Materials Science
Biomedical Engineering

Background:

Disposable plastic syringes are widely used in medical and research settings.
Potential leaching of chemical species from plastic materials into solutions is a concern.

Purpose of the Study:

To investigate the potential leaching of reactive species from disposable sterile plastic syringes.
To identify the nature of any leached free radicals.

Main Methods:

Analysis of fluids held in disposable sterile plastic syringes.
Electron paramagnetic resonance (EPR) spectroscopy was used to detect and characterize free radicals.

Main Results:

Free radicals were detected leaching from disposable sterile plastic syringes into contained fluids.

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The observed free radical was identified as a nitroxide (aminoxyl radical) based on its EPR spectrum.

The aqueous solution EPR spectrum exhibited a characteristic 1:1:1 triplet with a hyperfine splitting constant of 16.9 G.

Conclusions:

Disposable sterile plastic syringes can be a source of nitroxide free radicals.
The leaching of these radicals may have implications for sensitive assays and experiments.
Further research is needed to assess the impact of these leached radicals in various applications.