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Norepinephrine inhibits human natural killer cell activity in vitro
1Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.
The International Journal of Neuroscience
|May 1, 1991
Abstract:
The effect of norepinephrine on human NK cell activity was investigated using a flow cytometry assay. NK cell activity was found to be inhibited by direct addition of norepinephrine to lymphocyte/target cell mixtures in a dose-dependent fashion. This inhibitory effect of norepinephrine was blocked by propranolol but not by atenolol. The results suggest that norepinephrine has a negative influence on NK cell activity and that the effect of norepinephrine is mediated via beta 2-adrenoceptors.