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Bone changes in congenital cytomegalic inclusion disease
A E McCandless1, C Davis, E G Hall
1Alder Hey Children's Hospital, Eaton Road, Liverpool L12 2AP, England.
Archives of Disease in Childhood
|February 1, 1975
Summary
Cytomegalic inclusion disease (CID) in a newborn infant presented with significant bone changes in the long bones. This case highlights potential skeletal manifestations of congenital cytomegalovirus infection.
Area of Science:
- Pediatrics
- Neonatology
- Medical Imaging
Background:
- Cytomegalic inclusion disease (CID), a congenital viral infection, can have diverse clinical presentations.
- Skeletal abnormalities are not commonly emphasized in the initial diagnosis of congenital cytomegalovirus (CMV) infection.
Purpose of the Study:
- To report a rare case of congenital cytomegalic inclusion disease (CID) with prominent bone changes.
- To highlight the diagnostic utility of skeletal imaging in neonates with suspected congenital cytomegalovirus (CMV) infection.
Main Methods:
- Case report of a female infant with congenital cytomegalic inclusion disease (CID).
- Radiographic examination (X-rays) of tibiae and femora to assess bone changes.
- Review of maternal and perinatal history, including placental examination.
Main Results:
- The infant presented with cytomegalic inclusion disease (CID) and notable bone abnormalities in the tibiae and femora.
- The placenta showed multiple infarcts, suggesting a potential link to the fetal infection.
- Maternal history included a febrile illness during the seventh month of gestation, diagnosed as influenza.
Conclusions:
- Congenital cytomegalic inclusion disease (CID) can manifest with significant skeletal changes, detectable via radiography.
- Skeletal imaging should be considered in the diagnostic workup of neonates with suspected congenital cytomegalovirus (CMV) infection.
- This case underscores the importance of considering a broad spectrum of clinical findings in congenital CMV.