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Updated: Aug 9, 2026
Murine Flexor Tendon Injury and Repair Surgery
Published on: September 19, 2016
[Experimental studies on decorin in suppression of postoperative flexor tendon adhesion in rabbits]
1Central Laboratory, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P R China.
Objective:
To study the effect of decorin in the suppression of postoperative flexor tendon adhesion.
Methods:
Eighteen Japanese large ear white rabbits underwent complete transection of the II digit flexor digitorum profundus tendon in zone I and defects immediately were repaired using the modified Kessler technique with 5-0 nonabsorbable monofilament suture. The site of the right repaired tendon was then injected with 100 microl of decorin (0.25 mg/ml) as test toe, the site of the left repaired tendon with 100 microl of PBS as control toe. In every group, rabbits were killed and the feet were prepared for biomechanical testing, macroscopic examination and histological inspection.
Results:
In every group, biomechanical testing demonstrates that the sliding distances and the ranges of motion significantly increased in the test toe compared with the control toe (P < 0.05); macroscopic examination demonstrated that the tendon adhesions of the test toe were significantly reduced when compared with the control toe. In the tese toe, hematoxylin and eosin staining revealed that the hyperplasia of fibroblast was significantly delayed and the collagen fibrils arranged regularly and had the normal diameters.
Conclusion:
Decorin can significantly reduce the flexor tendon adhesion formation, adjust collagen fibrillogenesis and promote the tendon healing.
