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Nonallergic rhinitis with eosinophilia syndrome
Current Allergy and Asthma Reports
|April 4, 2006
Summary
Nonallergic rhinitis with eosinophilia syndrome (NARES) presents with allergy-like symptoms but without allergies, characterized by high nasal eosinophils and often anosmia. It is linked to nasal polyps and requires intranasal corticosteroid treatment.
Area of Science:
- Otolaryngology
- Allergy and Immunology
- Pathophysiology
Background:
- Nonallergic rhinitis with eosinophilia syndrome (NARES) mimics allergic rhinitis but lacks atopy.
- Key features include >20% eosinophils in nasal cytology and anosmia.
- The pathophysiology involves chronic eosinophilic inflammation and potential mast cell involvement.
Purpose of the Study:
- To define the clinical syndrome of NARES.
- To elucidate the pathophysiology of NARES.
- To identify risk factors and treatment options for NARES.
Main Methods:
- Diagnosis based on clinical symptoms, negative allergen skin testing, and nasal cytology.
- Pathophysiological mechanisms explored through cellular and molecular analysis.
- Association with other conditions and treatment efficacy evaluated.
Main Results:
- NARES is characterized by eosinophilic nasal inflammation, anosmia, and absence of atopy.
- It is a precursor to nasal polyposis, aspirin sensitivity, and obstructive sleep apnea.
- Intranasal corticosteroids are the primary treatment.
Conclusions:
- NARES is a distinct clinical entity with significant associated risks.
- Understanding its pathophysiology is crucial for effective management.
- Targeted treatments, primarily intranasal corticosteroids, are effective.
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