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Treating allergic rhinitis in pregnancy.

Vincent Piette, Jean-Pierre Daures, Pascal Demoly

    Current Allergy and Asthma Reports
    |April 4, 2006
    PubMed
    Summary
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    Pregnant women with allergic rhinitis can safely use certain medications. Guidelines suggest benefit often outweighs risk for treatments like inhaled glucocorticosteroids and some antihistamines.

    Area of Science:

    • Obstetrics and Gynecology
    • Allergology
    • Pharmacology

    Background:

    • Allergic rhinitis affects numerous pregnant women, necessitating careful drug selection.
    • Physiological changes during pregnancy can impact upper airway function.
    • Published evidence-based guidelines exist for managing allergic rhinitis in pregnancy.

    Purpose of the Study:

    • To review the safety and efficacy of medications for allergic rhinitis during pregnancy.
    • To provide guidance on drug selection considering potential risks and benefits.

    Main Methods:

    • Review of existing evidence-based guidelines and pharmacological data.
    • Analysis of drug safety profiles in animal studies and human use during pregnancy.
    • Assessment of risks versus benefits for different medication classes.

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    Main Results:

    • Inhaled glucocorticosteroids (e.g., beclomethasone, budesonide) show no evidence of teratogenicity in humans.
    • Certain H1-antihistamines are considered safe for use during pregnancy.
    • Most oral decongestants (excluding pseudoephedrine) are teratogenic in animals; intranasal decongestant data is limited.
    • Pregnancy is not a contraindication for immunotherapy.

    Conclusions:

    • Medication for allergic rhinitis in pregnancy should be prescribed when benefits clearly exceed risks.
    • Inhaled glucocorticosteroids and select antihistamines represent safer options.
    • Immunotherapy can be continued during pregnancy.